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Trivalent Chromiumns, GTF and Diabetes

BACKGROUND
In 1957 Dr. Mertz and Dr. Schwarz discovered that the experimental rats showed symptoms of poor glucose tolerance. It was then discovered after many experiments that the glucose tolerance of sick rats was restored if they were given an extract of hog liver cells. The two men hypothesized that the extract contained a certain factor that can eliminate poor glucose tolerance and regulate blood sugar, and they named this substance Glucose Tolerance Factor (GTF). After further research, Dr. Mertz and Dr. Schwarz finally discovered in 1959 that a substance similar in function to GTF could be isolated from brewer’s yeast. They confirmed that this substance contained a core of trivalent chromium, which was bound to some minerals, amino acids, and vitamins.

TRIVALENT CHROMIUM
Trivalent chromium compounds are commonly found is soil in most regions of the world. People obtained trivalent chromium by eating foods with natural concentrations derived from the soil. For the past half-century, modern agriculture has relied on chemical fertilizer, such as seasonal replenishment of nitrogen, potassium, and phosphorus. Over the years, the other naturally occurring essential minerals and trace elements, including chromium, have been exhausted in the soil and not replenished. Thus, most of our foods are chromium deficient at the level of agricultural production.
Food processing further reduces the chromium by as much as 90 percent. The result is widespread nutritional chromium deficiency of human body. Trivalent chromium is the most stable form and important in human glucose metabolism. Average dietary absorption ranges of chromium from 0.4% to 3%. Because most chromium compounds are soluble at the pH of the stomach, but less soluble hydroxides may form as pH is increased in intestine. And inorganic chromium easily undergoes olation with dietary fibers to form huge complex that will be very difficult to be absorbed by intestine.
So the organic forms of chromium as supplement are required to enhance the absorption rate of intestine. It is known that organic forms are absorbed at least 5 to 10 times more effectively than chromium chloride. As many as 90 percent of all American diets are low in chromium, because:
(1) soil depletion
(2) refined foods;
(3) excessive sugar consumption;
(4) lack of exercise; and
(5) obesity. As a result, the diabetes rate has tripled since 1958 and now accounts for 15 percent of the nation's health care budget.

GTF
GTF is short for glucose tolerance factor. GTF exists in all human tissues, and serves mainly to maintain the body’s normal sugar metabolism. Because it transports glucose into all cells in the body in coordination with insulin and insulin receptors, it is known as “glucose tolerance factor.” GTF must be present for insulin to activate insulin receptors. GTF is a complex material containing a core of trivalent chromium plus minerals, vitamin, and amino acids.

RELATIONSHIP BETWEEN GTF AND DIABETES
Glucose Tolerance Factor (GTF) is sometimes also known as “insulin booster.” Insulin must interact with GTF and insulin receptor to successfully send glucose into cells so it can be converted to energy. GTF can therefore be said to boost the biological activity of insulin and enhance the insulin receptors’ sensitivity.
By promoting the binding of insulin and insulin receptors and increasing the permeability of the cell membrane, GTF enables blood sugar to enter cells.
GTF thus helps insulin accomplish its function of reducing blood sugar. As long as the elements of insulin, GTF, and insulin receptors are functioning properly, insulin can play its role as the body’s sole hormone responsible for reducing blood sugar. But if any one of these three elements is missing, hypoglycemia and diabetes will occur. Among diabetics, 5~10% lack insulin, roughly 10% lack insulin receptors, and the remaining 80% lack GTF. Most people with diabetes got that way mainly due to a lack of GTF.

SAFETY TAKING OF GTF SUPPLEMENT
The purpose of taking GTF is to maintain healthy glucose, protein and lipid metabolism in our body. GTF is non-toxic. According to the evaluation report on USA Estimated Safe and Adequate Daily Dietary Intakes (US ESADDI) established by the US Environment Protection Agency, daily intake of chromium of not more than 350 times of the recommended dosage (200mcg) is within the safety limits. Safety limits of some other minerals, such as zinc, manganese, selenium etc, are only around 2 to 7 times of the daily intake.
According to a toxicity test report published by Anderson R. A. et. Al., after 20 weeks of feeding rats with does of chromium chloride equivalent to thousands times of human daily recommended intake, there is no evidence of toxification. This means that the safety dose of chromium chloride is several times of the ESADDI for humans. Also there is no evidence of toxic effects from supplemental chromium in the human studies. Therefore, GTF is a safe trace element for consumption as a supplement.

PRODUCT

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